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    Alzheimer's Life History Project

    Recruiting women with Alzheimer's disease for a UCLA research study! Also recruiting women without any cognitive impairment for our comparison group.

  • About the Study

    Alzheimer's disease (AD) is a serious condition that affects not just the brain, but the entire body. By looking at factors outside the brain that might contribute to AD, we hope to find new ways to prevent the disease before it causes major damage. We want to understand what is happening across women's lifespans that can build up their resilience against getting AD. Our research focuses on how hormones and the body’s ability to control inflammation might play special roles in increasing or decreasing the risk of developing AD. To do this, we study how a woman’s reproductive history (such as pregnancies and breastfeeding) and the bacteria and other microorganisms living in the body might influence the pathways in your body that can lead to AD.

     

    We are currently conducting a pilot study, recruiting women as participants along with their family members, from the Pacific Neuroscience Institute and Olive View-UCLA Medical Center. This pilot project was funded by a UCLA Hellman Fellowship and a UCLA Equity, Diversity, and Inclusion Faculty Career Development Award.

  • What You'll Do

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    Enroll & Interview with a Study Partner!

    With a study partner, someone who knows you well (like your adult child, your spouse, or a good friend), you will enroll in our study and be interviewed over zoom or phone call. We’ll ask questions about your life history, such as where you were born and whether you had pets as a child.

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    Blood Draw & Urine Collection

    You will have your blood drawn and urine collected either at your UCLA Health - affiliated hospital/clinic or at your home. Your blood will be drawn by one of our study's liscenced phlebotomists.

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    Gum Swab, Saliva Sample, & Smell Test

    You will be mailed a small sample collection kit to collect a gum and saliva sample. There will also be a quick questionnaire and scratch-and-sniff smell test. Once you collect your samples, you will contact us to pick up the samples.

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    Receive your $200 Amazon Gift Card!

    After completing our study, the participant will receive an electronic Amazon gift card for $200. If they are requested to provide an additional urine/blood sample, they will be eligible for an additional $50.

  • Are You Eligible?

    If you . . .

    have a diagnosis of at least probable Alzheimer's disease

    or Mild Cognitive Impairment (MCI) due to incipient or suspected Alzheimer's disease

    and . . .

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    • Are a woman aged 65 or older
    • Have a neurologist affiliated with UCLA Health
    • Are English-speaking
    • Do not have a diagnosis of any type of dementia or mild cognitive impairment (examples: Alzheimer's Disease, Parkinson's, fronto-temporal dementia)
    • Do not have an impact injury to the head that is thought to be the main cause of current cognitive impairment
    • Do not have severe cognitive or communication problems (examples: schizophrenia, autism)
    • Do not have HIV/AIDS
    • Do not have current cancers at Stage Ill+
    • Never had any brain cancer
    • Have not had chemotherapy or radiation therapy in the last year
    • Never had an ischemic or hemorrhagic stroke
    • Had no major surgery in the last month 

    You can also participate as part of our comparison group (alongside your study partner) if you have no cogntive impairment or dementia.

  • Meet The Team!

    Meet our coordination team! They keep our study running and organized.

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    Molly Fox, PhD

    Principal Investigator

    Associate Professor

    Department of Anthropology

    Department of Psychiatry and Behavioral Sciences

    UCLA

     

    Dr. Fox is a human biologist with a research program that explores how women’s social, cultural, and physical environments influence their own biological development and that of their children. By studying the human female life cycle, her work addresses questions related to women’s health and intergenerational processes between grandmothers, mothers, and infants. Some of the key topics of her research include (a) the transgenerational effects of socio-cultural stressors experienced by women in ethnic minority communities; (b) how women’s reproductive histories affect risk of Alzheimer’s disease; and (c) how social support from family confers health benefits to pregnant women. See mollyfox.strikingly.com

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    Jennifer Bramen, PhD

    Co-Investigator

    Senior Research Scientist

    Brain Health Center

    Pacific Neuroscience Institute

     

    With a passion for bridging the gap between translational research and clinical implementation, Dr. Bramen currently serves as a Senior Research Scientist at the Pacific Neuroscience Institute Foundation, which houses its memory research program within the Pacific Brain Health Center (PBHC), an outpatient dementia care clinic and center of excellence at Pacific Neuroscience Institute (partnered with the Providence Health system). At PBHC, Dr. Bramen collaborates closely with clinician-scientists to facilitate the integration of research findings into clinical practice. She leads the Neuroimaging Core, which provides neuroimaging-based biomarkers and supports automated data abstraction from the electronic health record to facilitate a better understanding clinical outcomes and measure the efficacy of clinical trials. Dr. Bramen’s research primarily focuses on interventions for Alzheimer’s disease and related dementias.

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    S. Madigan Durham

    Study Coordinator

    Graduate Student

    Biology with Specialization in Evolutionary Medicine

    UCLA

     

    Madigan Durham is currently pursuing her Masters in Biology at UCLA with goals to pursue a career in academia. Since joining the team in 2023, she takes the lead in mentoring our team of undergraduate student researchers when it comes to all their research endeavors within the realm of our study and more. Aside from Madigan's own independent projects in the lab, she also has a hand in sorting our data through our codebook, enrolling and interviewing participants, and even biosample analysis.

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    Desiree Eshraghi

    Study Coordinator & Lab Manager

    B.S. in Psychobiology & Disability Studies Minor

    UCLA

     

    Desiree Eshraghi is a recent graduate from UCLA with plans to pursue medical school. As a member of the our lab's coordination team since 2020, Desiree is an integral part to our study's efficiency. Aside from enrolling and interviewing pariticipants, editing our codebook, and facilitating our research assistant trainings and projects, Desiree also manages many of the study's inner workings. She tracks our participants, clearly communicates with our current and future partnering hospitals, promotes our study, maintains IRB aproval, and more!

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    Melanie Krahn

    UCLA IRB Manager

    B.A. in Anthropology & Global Health Minor

    UCLA

     

    Melanie Krahn is an aspiring physician and recent UCLA graduate currently enrolled in a postbaccalaureate program at CU Boulder. As our UCLA IRB manager, Melanie ensures our primary IRB documents are always approved by UCLA IRB with consistent ammendments and updates. She has also been a part of our team enrolling and interviewing participants with their study partners since 2022.

  • Our Research Assistants!

    Meet our research assistants! Our study wouldn't be possible without their hard work.

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    Ingrid Cely, MS

    Graduate Student

    Molecular Toxicology

    UCLA

     

    Despite her busy schedule working towards her PhD in Molecular Toxicology, Ingrid has been an essential mentor to our biosample analysis team since 2022. She has played a role in nearly all of our wet lab research from updating our protocols to training new onboards.

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    Lexi Tempera

    Research Assistant

    B.S. in Microbiology,

    Immunology, and Genetics

    UCLA

    Lexi began her work with the ALH project as part of the bioprocessing team in 2022. Now a post-baccalaureate scholar at Weill Cornell researching the gut-brain axis, Lexi hopes to pursue a PhD in Immunology.

     

     

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    Minh-Anh Pham

    Research Assistant

    Molecular, Cellular,

    Developmental Biology '26

    UCLA

    Minh-Anh has been involved in enrolling and interviewing patients and working on the codebook for the study since Spring 2024. In her free time, she enjoys reading and playing badminton.

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    Ruby Wu

    Research Assistant

    Psychobiology '26

    UCLA

     

    Ruby first joined the lab as part of our MRI team during her sophomore year, and now she's on the enroll and interview team working with participants and their families. Ruby hopes to continue making more progress in the future!

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    Darren Chen

    Research Assistant

    B.S. in Physiological Sciences

    & Biomedical Research Minor

    UCLA

    Darren joined the lab in January 2024, and is currently on the bioprocessing and data analysis teams. After graduating from UCLA, he currently works as a medical scribe. He hopes to attend medical school and become a physician in the future.

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    Kaleigh Olla

    Research Assistant

    B.S. in Psychobiology

    & Disability Studies Minor

    UCLA

    Since summer 2023, Kaleigh has been enrolling and interviewing participants as well as working on the bioprocessing team. After graduating from UCLA, she has been working as a medical assistant amid the process of applying to medical school.

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    Ann Ding

    Research Assistant

    Molecular, Cellular,

    Developmental Biology '26

    UCLA

    Ann has been working on developing the study's medical records codebook and recruiting/ enrolling study participants since Winter 2024. She is currently an undergraduate student at UCLA and hopes to become a physician in pediatric immunology.

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    Saba Honarvar

    Research Assistant

    Psychobiology

    & Biomedical Research Minor '26

    UCLA

    Saba has been interviewing participants for the Alzheimer's study since Fall 2024. After graduating from UCLA, she plans to attend medical school with the goal of becoming a cosmetic injector and eventually owning her own medical spa.

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    Anjali Kalindi

    Research Assistant

    Public Health '26

    UCLA

     

    As part of our team, Anjali assists in codebook and bioprocessing teams. She aspires to pursue an MD-MPH degree and is fascinated by the opportunity to examine the biological and social underpinnings of health.

     

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    Emily Zhu

    Research Assistant

    Neuroscience

    & Brain and Behavioral Health Minor '25

    UCLA

    Emily has been working with Dr. Fox and the rest of the team since Fall 2023. After a year on the neuroimaging team, she now helps contact and interview potential participants for the study. Emily hopes to work in the biosciences industry after she graduates.

     

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    Amy Mai

    Research Assistant

    Psychobiology'25

    UCLA

     

    Amy began her role as a phlebotomist in Fall 2023, where she collected and processed blood samples for the ALH project. Currently, she is an undergraduate student applying to medical school, actively working as a phlebotomist and medical assistant.  

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    Emma Dixon

    Medical Student

    B.S. in Biology

    & Classical Civilization

    UCLA

    Since joining the lab in 2021, Emma has pursued her research interests in biological anthropology and evolutionary medicine while completing her medical degree.

  • Our Alumni

    Thank you to all our past study members, from past coordinators to research assistants!

    Study Coordiantors

    Davis Mai

    Lorena Espinoza

    Amanda Reshke

    Graduate Researchers

    Hash Brown Taha

    Ainsley Brown

    Michael Parrish

    Andrew Baleyan

     

    Undergraduate Researchers

    Megan Blatt

    Cate Remphrey

    Briauna Archer

    Joan Moci

    Karina Acevedo

    Bethany Ru

    Megan Kirschner

    Paulina Salas

    Sunny Xiao

    Allison Whang

    Nandini Borkar

     

  • Our Relevant Publications

    Molly Fox. Evolutionary Perspectives on Alzheimer’s Disease. (2022) In: Evolutionary Psychiatry: Current Perspectives on Evolution and Mental Health, edited by Dr Riadh Abed and Dr Paul St John-Smith. Cambridge University Press. [book chapter]

     

    Hanadi Ajam Oughli, Sarah Nguyen, Prabha Siddarth, Molly Fox, Michaela Milillo, Helen Lavretsky. (2022) The Effect of Cumulative Lifetime Estrogen Exposure on Cognition in Depressed versus Non-Depressed Older Women.  Journal of Geriatric Psychiatry and Neurology. online ahead of print. doi: 10.1177/08919887221090216.

     

    Molly Fox, Prabha Siddarth, Hanadi Ajam Oughli, Sarah A Nguyen, Michaela M Milillo, Yesenia Aguilar, Linda Ercoli, Helen Lavretsky. (2021) Women who breastfeed exhibit cognitive benefits after age 50. Evolution, Medicine, and Public Health. 9(1):322-31

     

    Molly Fox, Delaney A. Knorr, Kacey M. Haptonstall. (2019) Alzheimer's disease and symbiotic microbiota: an evolutionary medicine perspective. Annals of the New York Academy of Sciences. 1449(1):3-24. DOI: 10.1111/nyas.14129

     

    Molly Fox. (2018) ‘Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions. Aging Research Reviews. 47 (2018) 140-148, doi: 10.1016/j.arr.2018.07.008 http://bit.ly/evmedAlzreview

     

    Molly Fox, Carlo Berzuini, Leslie A. Knapp, Laura M. Glynn. (2018) Women's pregnancy life-history and Alzheimer's risk: can immunoregulation explain the link? American Journal of Alzheimer’s Disease & Other Dementias. doi: 10.1177/1533317518786447
    http://bit.ly/pregalzimmune 

     

    Laura M. Glynn*, Mariann A. Howland*, Molly Fox*. (2018) Maternal programming: Application of a developmental psychopathology perspective. Development and Psychopathology. 30 (2018), 905–919. http://bit.ly/maternalprogramming

     

    Molly Fox, Carlo Berzuini, Leslie A. Knapp. (2013) Cumulative estrogen exposure, number of menstrual cycles, and Alzheimer's risk in a cohort of British women. Psychoneuroendocrinology. 38(12), 2973–2982. doi: 10.1016/j.psyneuen.2013.08.005. http://www.sciencedirect.com/science/article/pii/S0306453013002941

     

    Molly Fox, Corey L. Fincher, Paul W. Andrews, Leslie A. Knapp. (2013) Hygiene and the world distribution of Alzheimer’s Disease. Evolution, Medicine, and Public Health. doi: 10.1093/emph/eot015. http://emph.oxfordjournals.org/content/2013/1/173

     

    Molly Fox, Carlo Berzuini, Leslie A. Knapp. (2013) Maternal breastfeeding history and Alzheimer’s risk. Journal of Alzheimer’s Disease. 37 (4), 809-821. doi: 10.3233/JAD-130152 http://iospress.metapress.com/content/gr8353774g62515l/

     

    Undergraduate Research Presentations

    KALEIGH OLLA and Dr. Molly Fox. (2024). "Determining the effect of hormonal birth control usage on cognitive outcomes in postmenopausal American women." 

     

    OWEN POGUE and Dr. Molly Fox. (2024). "Exploring the link between menopause, estrogen loss, and Alzheimer's disease in women."

     

    BRIAUNA ARCHER*, DESIREE ESHRAGHI*, SUNNY XIAO*, Davis Mai, Lorena Espinoza, and Dr. Molly Fox. (2022). “Menopausal onset and symptoms associated with Alzheimer’s disease onset.”

  • Contact Us

    You can also reach us at uclaresearchproject@gmail.com!